Molecular Genetics
The Kallam Anji Reddy Molecular Genetics Laboratory, established with the generous support of Dr K Anji Reddy of Dr Reddy’s Laboratories, Hyderabad, conducts research leading to the understanding of underlying molecular mechanisms in various inherited eye disorders. This laboratory has facilities for advanced research in molecular genetics and molecular biology and is equipped with thermal cyclers, gel documentation units, spectrophotometer, electrophoresis equipment, dHPLC – a Real Time PCR and two automated DNA sequencers.
The lab’s primary focus lies in identifying and characterizing the genes involved in ocular disorders, understanding their mutation spectrum, screening SNPs that could be potential risk factors for the disease condition and generating haplotypes to understand the origin, evolution and differentiation of the mutations. Based on this an attempt is made towards establishing a genotype-phenotype correlation that may be useful to monitor prognosis. Identification of gene mutations and variants can further lead to devising molecular diagnostics for rapid screening and early intervention.
Principle investigators
Subhabrata Chakrabarti
Dr. Subhabrata Chakrabarti is a genome biologist trained in India and at the National Eye Institute at NIH, USA. His pioneering research on the functional genomics of glaucoma and Age-related Macular Degeneration (AMD) have provided molecular insights into disease pathogenesis for these conditions.
He is a doctoral supervisor for various Universities in India and abroad and regularly supervises Ph.D. candidates and post-doctoral fellows.
Inderjeet Kaur
Dr. Inderjeet Kaur works with a focus on the genetics of eye disease. Her main research interest is in understanding the molecular mechanisms in complex eye diseases, age-related macular degeneration (AMD), myopia and glaucoma.
Her research on AMD and myopia has been hailed widely as pioneering work in the field from India.
Anshuman Verma
Dr. Anshuman Verma’s research focuses on the diagnosis and screening of genetic ocular disorders and translating genetic insights into meaningful translational outcomes. One such translational project, currently being initiated, focuses on CRISPR-based gene editing of SLC4A11, a gene associated with congenital hereditary endothelial dystrophy (CHED).
His overarching goal is to advance the diagnosis and understanding of genetic ocular disorders and contribute to the development of regenerative-based treatments.
Aatish Mahajan
Dr. Aatish Mahajan is working on the effect of maternal diabetes during pregnancy on placental epigenetics and its association with retinal development and risk of retinopathy in infants. He has a PhD in Biochemistry and two post doctoral positions in the US before joining LVPEI.
He is working on risk prediction and early screening of babies with Retinopathy of Prematurit
Publications
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Molecular Genetics work at LVPEI is at the cutting-edge thanks to the generous support of donors like you.
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If you are interested in the work we do, and would like to work with us, do get in touch.
